Cells in Tissues & the Extracellular World

collagen

/ KOL-uh-jen /

Think of the steel cables inside a suspension bridge or the reinforcing rods in concrete: thin on their own, but bundled together they bear enormous pulling loads. Your body needs the same reinforcement to keep skin, tendons, and bones from tearing apart. Collagen is that reinforcement — the tough, rope-like protein that gives animal tissues their tensile strength, and the single most abundant protein in your body.

Collagen is built from three protein chains wound tightly around each other into a stiff triple helix, like three strands twisted into a rope. These rope units then line up side by side and bundle into thicker and thicker fibrils and fibers, so the strength scales up from molecule to visible fiber. The triple helix depends on an unusual, regularly repeating amino-acid pattern and on a chemical step that adds extra hydroxyl groups to certain amino acids — a step that requires vitamin C. There are many types of collagen tuned for different jobs: rope-like fibers in tendon and skin, sheet-forming collagen in the basement membrane, and others.

Collagen matters because it is the main load-bearing material of the body's connective tissues: tendons that transmit muscle force, the dermis that gives skin its toughness, the scaffold of bone before it is mineralized, and the framework of most organs. Its importance is clear from what happens when it fails. Without vitamin C the body cannot finish building collagen properly, leading to scurvy — bleeding gums, poor wound healing, and weak tissues — which is why sailors who lacked fresh fruit fell ill. Inherited collagen defects cause fragile bones or overly stretchy, easily damaged skin and joints.

Sailors on long voyages without fresh fruit developed scurvy: lacking vitamin C, their bodies could not finish building collagen, so old wounds reopened, gums bled, and skin grew fragile.

Collagen needs vitamin C to be built properly — and the body's strength depends on it.

The collagen in skin-care creams cannot be absorbed and woven into your own tissue; the body builds collagen itself from amino acids, and that process — not eating collagen — is what vitamin C supports.

Also called
collagen fiber胶原蛋白膠原蛋白