The Chemistry of Life

ATP

/ ay-tee-PEE /

Cells need a way to pay for work — pumping ions, building molecules, moving parts, contracting muscle. They do not run on raw food directly; they run on a small, rechargeable energy molecule called ATP, which acts as the universal cash of the cell.

ATP stands for adenosine triphosphate. It is essentially a nucleotide — an adenine base attached to a sugar — with a tail of three phosphate groups. The energy lives in the bonds linking those phosphates: snapping off the last phosphate (turning ATP into ADP, adenosine diphosphate) releases a usable burst of energy that the cell harnesses to power a reaction. The cell then spends energy from food to reattach a phosphate, recharging ADP back into ATP. This constant cycle of discharge and recharge is the ATP–ADP cycle.

The genius of ATP is that it is a standard, universal denomination of energy. Instead of every reaction needing its own custom fuel, the cell converts the energy in food into ATP, and ATP then pays for almost everything. A single cell may recycle its body weight in ATP many times over in a day — not by storing a vast amount, but by spending and remaking the same molecules over and over, like cash circulating through an economy.

Every time a muscle fiber contracts, it spends ATP; sprint hard and you burn through your ready ATP in seconds, which is one reason an all-out dash cannot last long.

Muscles run on ATP — and the cell's ready supply lasts only seconds before it must be remade.

ATP is energy currency, not energy storage: cells keep very little of it on hand and constantly remake it. Long-term energy is banked as fat and carbohydrate, then converted to ATP only as needed.

Also called
adenosine triphosphateenergy currency of the cell腺苷三磷酸